{"product_id":"new-product-225709","title":"EPC1 polyclonal antibody","description":"\u003cp\u003eEnhancer of Polycomb 1 (EPC1) is a member of the Polycomb group (PcG) proteins. EPC1 interacts with the transcriptional repressor E2F6. In proliferating cells, the proliferation-specific PcG, EZH2, associates with this E2F6-EPC1 complex, which may regulate genes required for cell cycle promotion. EPC1 also interacts with a member of the RING finger protein family (RFP), and this complex functions as a transcriptional repressor. Lastly, EPC1 is a com-ponent of the NuA4 histone acetyltransferase (HAT) complex, which transcriptionally activates certain genes by acetylation of Histones H4 and H2A. This acetylation may alter nucleosome-DNA interactions and promote interaction of the modified histones with other positive transcription regulators. The HAT complex may play a role in oncogene\/proto-oncogene growth induction, tumor suppressor growth arrest, replicative senescence, apoptosis and DNA repair.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse","offer_id":47661901119768,"sku":"BS7870","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_62395ef8-ac31-43f3-bf4d-6ff28e4f4317.jpg?v=1707470699","url":"https:\/\/danabiosci.com\/products\/new-product-225709","provider":"Dana Bioscience","version":"1.0","type":"link"}