{"product_id":"new-product-225673","title":"DAP polyclonal antibody","description":"\u003cp\u003eIn contrast to growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved cytoplasmic region called the “death domain”. DAP-1 (for death associated protein-1) interacts with the death domain of TNF-R1 and can trigger programmed cell death in a variety of cell lines, as well as suppress NFκB\/Rel activity. DAP-3 is a positive mediator of programmed cell death; overexpressed intact full-length protein is required in order to induce apoptosis. During apotosis, the caspase-activated DAP-5 can mediate CAP-independent translation at least from its own internal ribosome entry site, thus resulting in a positive feedback loop responsible for the continuous translation of DAP-5. DAP-5 is also required for cellular differentiation, as it controls specific gene expression pathways.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47661898858776,"sku":"BS7941","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_bae58ebd-2cd9-40e6-adc4-ac6c60304958.jpg?v=1707470531","url":"https:\/\/danabiosci.com\/products\/new-product-225673","provider":"Dana Bioscience","version":"1.0","type":"link"}