{"product_id":"new-product-225617","title":"TSLP polyclonal antibody","description":"\u003cp\u003eThymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The gene encoding murine TSLP maps to chromosome 18 and its human homologue is expressed in several tissues, including heart, liver and prostate. TSLP mediates its function by binding to a receptor complex. TSLP first binds with low affinity to a TSLP-specific chain designated TSLPR, and then forms a high affinity complex with the IL-7Rα subunit, which explains the overlapping biological properties between TSLP and IL-7. Both TSLP and IL-7 induce phosphorylation of the transcription factor Stat5, but unlike IL-7, TSLP-mediated signaling does not activate the JAKs. TSLP prevents apoptosis and stimulates the proliferation of myeloid cells, which is supported by the coexpression of TSLPR and IL-7RRα on monocytes and dendritic cells.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47661896663320,"sku":"BS8051","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_290802f0-9eba-4329-8436-ef150e3e7dfa.jpg?v=1707470244","url":"https:\/\/danabiosci.com\/products\/new-product-225617","provider":"Dana Bioscience","version":"1.0","type":"link"}