{"product_id":"new-product-225527","title":"ISL1 polyclonal antibody","description":"\u003cp\u003eIslet-1 (ISL1 transcription factor, LIM\/homeodomain) and Islet-2 (ISL2 transcription factor, LIM\/homeodomain) contain amino-terminal LIM domains and a carboxy-terminal homeodomain and both influence developmental events. Islet-1 influences embryogenesis of the pancreatic islets of Langerhans and neural tube motor neuron differentiation. In developing mouse teeth, Islet-1 mediates patterning of dentition as an activator of Bmp4 expression in incisor (distal) areas of the stomatodeal epithelium. Islet-1 expression defines cardiac progenitor cell populations and is required for normal cardiac development and asymmetry. Islet-2 activity in newly generated motor neurons permits the diversification of visceral and somatic motor neuron subtypes in the developing spinal cord. Murine Islet-2 specifies retinal ganglion cell (RGC) laterality by repressing an ipsilateral pathfinding program unique to the ventral-temporal crescent (VTC) of RGCs in a Zic2- and EphB1-dependent manner.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47661876707608,"sku":"BS8173","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_fbf1d74e-ff98-4ee7-9ef0-158b6cdf019d.jpg?v=1707469747","url":"https:\/\/danabiosci.com\/products\/new-product-225527","provider":"Dana Bioscience","version":"1.0","type":"link"}