{"product_id":"new-product-225510","title":"PTPRN polyclonal antibody","description":"\u003cp\u003eProtein tyrosine phosphatases, or PTPs, are type I transmembrane proteins,membrane-associated proteins or proteins localized in nuclei. Examples of transmembrane PTPs are LAR, PTPα, PTPβ, PTPγ, PTPδ, PTPε, PTPζ, PTPκ\u003cbr\u003e\nand PTPμ. Transmembrane PTPs play diverse roles in a variety of cellular processes during development and in adult tissues. PTP IA-2 (PTP insulinoma-associated protein 2), also known as PTPRN, IA2, ICA512 (islet cell antigen 512) or RPTPN, is a receptor-type PTP-like protein containing a transmembrane region, an intracellular PTP-like domain and an extracellular Nterminus.Localizing to secretory granules, PTP IA-2 is exclusively expressed in neuroendocrine cells (including pancreatic islet cells) and is believed to participate in the regulation of secretory granule exocytosis. PTP IA-2 is an\u003cbr\u003e\nautoantigen and contributes to Insulin-dependent diabetes mellitus (IDDM). The detection of autoantibodies against PTP IA-2 is commonly used as a diabetes diagnosis marker.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47661872316696,"sku":"BS8189","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_dd2f76e4-676f-48bf-9f4b-d5b2358eac96.jpg?v=1707469658","url":"https:\/\/danabiosci.com\/products\/new-product-225510","provider":"Dana Bioscience","version":"1.0","type":"link"}