{"product_id":"new-product-225447","title":"GALNT3 polyclonal antibody","description":"\u003cp\u003eThe UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosaminyl) to serine and threonine residues onto various proteins, thereby initiating mucin-type O-linked glycosylation in the golgi apparatus. GalNAc-T3, also known as GALNT3, HHS or HFTC, is a 633 amino acid single-pass type II membrane protein that localizes to the golgi and contains one ricin B-type lectin domain. Expressed at high levels in kidney, testis, skin and pancreas, GalNAc-T3 uses manganese and calcium as cofactors to catalyze the first reaction in O-linked oligosaccharide biosynthesis, namely the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on a target protein. Defects in the gene encoding GalNAc-T3 are the cause of hyperphosphatemic familial tumoral calcinosis (HFTC) and hyperostosis-hyperphosphatemia syndrome (HHS). GalNAc-T3 is overexpressed in carcinoma tissue, suggesting a role in tumor development and metastasis.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse","offer_id":47661852459288,"sku":"BS8280","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_5077e2cb-e826-427c-a67c-c2bc25d24754.jpg?v=1707469296","url":"https:\/\/danabiosci.com\/products\/new-product-225447","provider":"Dana Bioscience","version":"1.0","type":"link"}