{"product_id":"new-product-225416","title":"KYNU polyclonal antibody","description":"\u003cp\u003eKynureninase, also known as L-kynurenine hydrolase, is a 465 amino acid cytoplasmic enzyme. Kynureninase is involved in two pathways; the degredation of L-kynurenine and the biosynthesis of the cofactor NAD(+). The main function of kynureninase is to catalyze the cleavage of L-kynurenine into anthranilic acid and of L-3-hydroxykynurenine into 3-hydroxyanthranilic acid, exhibiting a preference for the L-3-hydroxy form. Kynureninase forms a homodimer, uses pyridoxal phosphate as a cofactor and is inhibited by o-methoxybenzoylalanine (OMBA). Kynureninase is widely expressed, with highest levels found in lung, placenta and liver. Deficiency in kynureninase leads to hyperkynureninuria, a disorder characterized by the inability to break down tryptophan to nicotinic acid (vitamin B6). Increased levels of kynureninase activity are observed in systemic and cerebral inflammatory conditions.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47661836665112,"sku":"BS8320","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_81c0e939-18e1-48f6-9f1d-7b0875a7f2f6.jpg?v=1707469143","url":"https:\/\/danabiosci.com\/products\/new-product-225416","provider":"Dana Bioscience","version":"1.0","type":"link"}