{"product_id":"new-product-225375","title":"RAE1 polyclonal antibody","description":"\u003cp\u003eNatural killer (NK) cells attack tumor and infected cells, but the receptors and\u003cbr\u003e\nligands that stimulate them are poorly understood. Two murine ligands for\u003cbr\u003e\nthe lectin-like receptor NKG2D, H60 and retinoic acid early inducible (Rae-\u003cbr\u003e\n1α, β, γ, δ and ε), are distant relatives of major histocompatibility complex\u003cbr\u003e\nclass I molecules. These molecules are encoded by Rae-1 and H60 minor\u003cbr\u003e\nhistocompatibility antigen genes on mouse chromosome 10 and show weak\u003cbr\u003e\nhomology with MHC class I. Expression of the NKG2D ligands is low or absent\u003cbr\u003e\non normal, adult tissues; however, they are constitutively expressed on some\u003cbr\u003e\ntumors and upregulated by retinoic acid. Ectopic expression of Rae-1 and\u003cbr\u003e\nH60 confers target susceptibility to NK cell attack. NKG2D binds to H60 with\u003cbr\u003e\napproximately 25-fold higher affinity than to Rae-1. Rae-1 and H60 compete\u003cbr\u003e\ndirectly for occupancy of NKG2D; therefore, NKG2D can be occupied by only one ligand at a time. Additionally, Rae-1 and H60 ligands of the NKG2D\u003cbr\u003e\nreceptor stimulate tumor immunity.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47661826277656,"sku":"BS8377","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_8c09a17d-33b0-4757-a108-72ad5d09c7ce.jpg?v=1707468959","url":"https:\/\/danabiosci.com\/products\/new-product-225375","provider":"Dana Bioscience","version":"1.0","type":"link"}