{"product_id":"new-product-225371","title":"RAPSN polyclonal antibody","description":"\u003cp\u003eThe RAPSN gene locus is located on chromosome 11p11.1-p11.2 and encodes a peripheral membrane protein. Rapsyn (receptor-associated protein of the synapse) is expressed in the postsynaptic membrane of skeletal muscle. Rap-syn is required for the clustering of nicotinic acetylcholine receptors (nAChR). Rapsyn self-associates through at least two of its seven tetra-tricopeptide repeats (TPRs). Rapsyn interacts with the large intracellular domain of the nAChR a subunit through the hydrophobic surface of the coiled-coil domain. Rapsyn modifies trafficking of AChR within the cell. Expression is essential for agrin-induced AChR clustering. Overexpression inhibits agrin-induced AChR clustering pathway. Absence of rapsyn causes deficit in the formation of postsynaptic specializations at neuromuscular synapse, which increases axonal branching and motonueron survival. Rapsyn plays a role in selective targeting of newly synthesized intracellular AChR to postsynaptic membrane.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47661825425688,"sku":"BS8379","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_2c2d7407-d89c-4a03-8a5f-945a9b2ee819.jpg?v=1707468945","url":"https:\/\/danabiosci.com\/products\/new-product-225371","provider":"Dana Bioscience","version":"1.0","type":"link"}