{"product_id":"new-product-225357","title":"SETMAR polyclonal antibody","description":"\u003cp\u003eSETMAR (SET domain and mariner transposase fusion gene-containing protein), also known as METNASE or Hsmar1, is a ubiquitously expressed fusion protein with histone-lysine N-methyltransferase activity and DNA-binding, DNA-looping and DNA-cleavage activities. Localizing to the nucleus, SETMAR contains one N-terminal SET domain which facilitates the histone-lysine methyltransferase activity (at H3-Lys4 and H3-Lys36) and a C-terminal transposase domain which is responsible for the DNA-binding, -looping and -cleavage activities. Both domains are essential for the proper function of SETMAR. SETMAR specifically functions in DNA repair but, on its own, SETMAR can only bind to 5’-TIR (terminal inverted repeats) in DNA. For interactions with non-TIR DNA, SETMAR (via its SET domain) binds to and forms a stable complex with the pre-mRNA processing protein PRP19. Due to alternative splicing events, two isoforms exist.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human","offer_id":47661822411032,"sku":"BS8398","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_7fbcca3d-1bc9-46d6-97a7-e62a22390931.jpg?v=1707468882","url":"https:\/\/danabiosci.com\/products\/new-product-225357","provider":"Dana Bioscience","version":"1.0","type":"link"}