{"product_id":"new-product-225333","title":"TSC22D3 polyclonal antibody","description":"\u003cp\u003eGlucocorticoid-induced leucine zipper (GILZ) is a leucine zipper protein ex-pressed in normal lymphocytes from thymus, spleen and lymph nodes. It is absent in nonlymphoid tissues including brain, liver and kidney. GILZ mediates the immunosuppressive effects of glucocorticoid hormones; its expression is induced in T cells by dexamethasone. GILZ protects T cells from an anti-CD3 antibody-induced apoptosis by inhibiting Fas and Fas ligand expression. It interferes with Egr-2, Egr-3, NFAT\/AP-1-inducible transcription factors and AP-1. The interaction of GILZ with c-Fos and c-Jun inhibits the binding of active AP-1 to its DNA consensus site in vitro. GILZ also binds NFkB subunits and inhibits the NFkB nuclear translocation. It inhibits T cell receptor-induced interleukin-2\/interleukin-2 receptor expression. The binding of GILZ to Raf-1 prevents Raf-MEK-ERK activation in the MAPK pathway. GILZ is expressed by normal macrophages in nonlymphoid tissues and by tumor-infiltrating macrophages in Burkitt lymphomas. The gene encoding human GILZ maps to chromosome Xq22.3.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47661816185112,"sku":"BS8433","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_36a2aef2-31a2-4de9-826f-9707c598eae7.jpg?v=1707468769","url":"https:\/\/danabiosci.com\/products\/new-product-225333","provider":"Dana Bioscience","version":"1.0","type":"link"}