{"product_id":"new-product-225211","title":"PFKFB3 polyclonal antibody","description":"\u003cp\u003ePhosphofructosekinase-2 (PFK-2) belongs to the phosphoglycerate mutase family and is required for the activation of cellular glycolysis. Within the glycolysis pathway, PFK-2 regulates the synthesis and degradation of fructose 2,6-bisphosphate (F2,6BP) by enzymatically catalyzing the phosphorylation of fructose-6-phosphate to form F2,6BP. F2,6BP functions as a potent activator for 6-phosphofructo-1-kinase that can then activate the glycolysis pathway. Various tissue-specific isoforms of PFK-2 are expressed, including the PFK-2 specific to the brain (br), the liver (liv) and the placenta (pl), and they are also differentially regulated and function as homodimers. A unique isoform, iPFK-2, is induced following proinflammatory stimuli, and it is also constituitively expressed in a variety of carcinoma cell lines, where it leads to an accumation of intracellular F2,6BP. In addition, the expression of iPFK-2 correlates to increases in DNA sysnthesis, suggesting that iPFK-2 may contribute to cellular transformation of cells and enhanced cellular proliferation.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse","offer_id":47661797212440,"sku":"BS8601","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_b4708fa1-fdd9-49ff-b32e-a152a8372caf.jpg?v=1707468144","url":"https:\/\/danabiosci.com\/products\/new-product-225211","provider":"Dana Bioscience","version":"1.0","type":"link"}