{"product_id":"new-product-225050","title":"SETD6 polyclonal antibody","description":"\u003cp\u003eSETD6 (SET domain-containing protein 6) is a 473 amino acid protein that belongs to the SETD6 family. Containing one SET domain, SETD6 is structurally similar to the Rubisco large subunit methyltransferase. SETD6 is a proteinlysine N-methyltransferase that specifically monomethylates “Lys-310” of the NFκB p65 subunit of NFκB complex, leading to down-regulate NFκB transcription factor activity. SETD6-mediated methylation renders NFκB p65 inert and attenuates NFκB p65-driven transcriptional programs, including inflammatory responses in primary immune cells. The SETD6-initiated lysine-methylation signaling cascade acts to restrain activation of NFκB-mediated inflammatory responses in diverse cell types.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47661774504216,"sku":"BS8794","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_3de39afc-3e7b-4dcb-a67a-741c2e1634a6.jpg?v=1707467293","url":"https:\/\/danabiosci.com\/products\/new-product-225050","provider":"Dana Bioscience","version":"1.0","type":"link"}