{"product_id":"new-product-225023","title":"SMYD3 polyclonal antibody","description":"\u003cp\u003eSET and MYND domain-containing 3 (SMYD3), a 428 amino acid protein, is a member of an RNA polymerase complex and plays a role in transcriptional regulation. SMYD3 methylates Lys 4 of histone H3, a specific tag for epigenetic transcriptional activation. The SMYD3 protein contains an N-terminal MYND-type zinc finger domain, followed by a SET domain, which shows methyltransferase activity. The presence of the heat-shock protein HSP 90α greatly enhances the methyltransferase activity of SMYD3. SMYD3 is expressed in testis and skeletal muscles and is overexpressed in a majority of colorectal carcinomas (CRCs), hepatocellular carcinomas (HCCs) and breast carcinomas (BCs). Inhibition of SMYD3 is a potential chemotherapeutic strategy.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse","offer_id":47661772505368,"sku":"BS8830","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_8a7476c0-2a4b-4c6e-bbca-4bed44a7f0fc.jpg?v=1707467174","url":"https:\/\/danabiosci.com\/products\/new-product-225023","provider":"Dana Bioscience","version":"1.0","type":"link"}