{"product_id":"new-product-224755","title":"E2F-1 (4G8) monoclonal antibody","description":"\u003cp\u003eThe E2F transcription factors are essential for regulation of the cell cycle. Physiological E2F is a heterodimer composed of an E2F subunit together with a DP subunit. Six members of the E2F family have been identified, and each E2F subunit has a DNA binding and a dimerization domain. E2F-1 to -5 activate transcription. E2F-1 to -3 bind pRb, and E2F-4 and -5 bind p107 or p130, and these interactions are under cell cycle control. E2F-1 has oncogenic properties in vivo and in vitro. E2F-1 can induce apoptosis through p53-dependent and -independent mechanisms. E2F-1 is stress-responsive, and is regulated by a PI3-kinase-like kinase family such as the ATM\/ATR kinases.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Mouse \/ Human,Rat","offer_id":47661747077400,"sku":"MB0176","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_892689ab-45a9-4a40-a51f-c6af66901ed3.jpg?v=1707465921","url":"https:\/\/danabiosci.com\/products\/new-product-224755","provider":"Dana Bioscience","version":"1.0","type":"link"}