{"product_id":"new-product-224451","title":"CaMKII polyclonal antibody","description":"\u003cp\u003eThe Ca2+\/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine\/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is a ubiquitously expressed serine\/threonine protein kinase that is activated by Ca2+and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes designated α, β, γ and δ, which may or may not be co-expressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10-40 fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory Threonine residue at position 177.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human, Mouse, Rat","offer_id":47661703168280,"sku":"BS90176","price":448.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_71729b1a-6325-4090-8499-0cc539e54c12.jpg?v=1707464576","url":"https:\/\/danabiosci.com\/products\/new-product-224451","provider":"Dana Bioscience","version":"1.0","type":"link"}