{"product_id":"new-product-223986","title":"Histone H2A.Z polyclonal antibody","description":"\u003cp\u003eHistone H2A.Z\/H2A.F\/Z (H2A\/z) is a 128 amino acid protein encoded by the human gene H2AFZ. Eukaryotic histones are basic and water soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA sequentially in a left-handed super-helical turn to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3 and H4) form the octamer, which is comprised of two H2A-H2B dimers and two H3-H4 dimers, creating two nearly symmetrical halves by tertiary structure. H2A.Z\/H2A.F\/Z is a variant Histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in tran-scription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of posttranslational modifications of histones, also called histone code, and nucleosome remodeling. H2A.Z\/H2A.F\/Z may be involved in the formation of constitutive heterochromatin and may be required for chromosome segregation during cell division.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human, Mouse, Rat","offer_id":47661627638040,"sku":"BS90640","price":448.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_ac1acd11-1c3a-4a04-8636-bfa56445d8b1.jpg?v=1707462252","url":"https:\/\/danabiosci.com\/products\/new-product-223986","provider":"Dana Bioscience","version":"1.0","type":"link"}