{"product_id":"new-product-223644","title":"Oct-3\/4 polyclonal antibody","description":"\u003cp\u003ePOU5F1 (POU domain, class 5, transcription factor 1), also known as octamer-binding transcription factor-3 (Oct-3, OTF3), octamer-binding transcription factor-4 (Oct-4, Otf-4) and Oct-3\/4, modulates embryonic stem (ES) cell populations by influencing lineage commitment. Oct-3\/4 sustains stem-cell self-renewal and differentiation pathways. Transcription factors containing the POU homeodomain regulate tissue-specific gene expression in lymphoid and pituitary differentiation and in early mammalian development. Oct-3\/4 is capable of inducing rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene. In humans, two Oct-3\/4 isoforms contribute to influencing the undifferentiated phenotype of ES cells. Oct-3\/4 pseudogenes localizing to human chromosomes 10 and 8 are reported to be transcribed in certain cancer cell lines and tissues.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human, Mouse","offer_id":47661602865432,"sku":"BS90981","price":448.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_5ab51e4b-ae6f-460e-8359-baf64295814a.jpg?v=1707460632","url":"https:\/\/danabiosci.com\/products\/new-product-223644","provider":"Dana Bioscience","version":"1.0","type":"link"}