{"product_id":"new-product-223629","title":"p27 Kip1 polyclonal antibody","description":"\u003cp\u003eCell cycle progression is regulated by a series of cyclin-dependent kinases consisting of catalytic subunits, designated Cdks, as well as activating subunits, designated cyclins. Orderly progression through the cell cycle requires the activation and inactivation of different cyclin-Cdks at appropriate times. A series of proteins has recently been described that function as \"mitotic inhibitors.\" These include p21, the levels of which are elevated upon DNA damage in G1 in a p53-dependent manner; p16; and a more recently described p16-related inhibitor designated p15. A p21-related protein, p27, has been described as a negative regulator of G1 progression and speculated to function as a possible mediator of TGFβ-induced G1 arrest. p27 interacts strongly with D-type cyclins and Cdk4 in vitro and, to a lesser extent, with cyclin E and Cdk2.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human, Rat","offer_id":47661601751320,"sku":"BS91000","price":448.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_b7816a98-1218-4d9a-ba40-7339ccd79e6e.jpg?v=1707460558","url":"https:\/\/danabiosci.com\/products\/new-product-223629","provider":"Dana Bioscience","version":"1.0","type":"link"}