{"product_id":"new-product-223553","title":"PKCβ polyclonal antibody","description":"\u003cp\u003eCalcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine\/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11\/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11\/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7\/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K\/AKT-dependent nitric oxide synthase (NOS3\/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human, Mouse","offer_id":47661583761688,"sku":"BS91081","price":448.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_5314b9c7-ad56-48a8-bcf0-2c5762814677.jpg?v=1707460079","url":"https:\/\/danabiosci.com\/products\/new-product-223553","provider":"Dana Bioscience","version":"1.0","type":"link"}