{"product_id":"new-product-223513","title":"PRP19 polyclonal antibody","description":"\u003cp\u003eThe spliceosome, the 0gigantic molecular machine that performs pre-mRNA splicing in eukaryotes, contains over 200 different proteins and five RNA molecules (U1, U2, U4, U5 and U6). Pre-mRNA splicing is essential to remove internal non-coding regions of pre-mRNA (introns) and to join the remaining segments (exons) into mRNA before translation. The PRP19-associated complex is required for stable association of U5 and U6 with the spliceosome after U4 is released. Changes within the spliceosome upon binding of the PRP19-associated complex include remodeling of the U6\/5' splice site interaction and destabilization of Lsm proteins to allow further interaction of U6 with the intron sequence.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human, Mouse, Rat","offer_id":47661579403544,"sku":"BS91118","price":448.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_a463dc9f-fe7f-4918-9f8c-acda649438e2.jpg?v=1707459841","url":"https:\/\/danabiosci.com\/products\/new-product-223513","provider":"Dana Bioscience","version":"1.0","type":"link"}