{"product_id":"new-product-223215","title":"USP7 polyclonal antibody","description":"\u003cp\u003eHAUSP (herpesvirus-associated ubiquitin-specific protease, USP7) is a ubiquitin-specific protease. HAUSP localizes predominantly to the nucleus, in a TD-dependent manner, where it associates with ND10. ND10 are small nuclear structures implicated in a variety of cellular processes including response to stress and interferons, oncogenesis, and viral infection. HAUSP binds strongly to Vmw110, a herpesvirus regulatory protein which has the ability to disrupt ND10. HAUSP, a novel p53-interacting protein, functions to deubiquitinize p53 in an important pathway for p53 stabilization. HAUSP strongly stabilizes p53 even in the presence of excess Mdm2, and also induces p53-dependent cell growth repression and apoptosis. The HAUSP protein is distributed in the nucleus in a micropunctate pattern with a limited number of larger discrete foci, some of which co-localize with PML in ND10. The gene encoding HAUSP maps to human chromosome band 16p13.2.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human, Mouse, Rat","offer_id":47661541753112,"sku":"BS91418","price":448.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_ce9e62c4-4890-4728-8dd4-2ec47009478d.jpg?v=1707458292","url":"https:\/\/danabiosci.com\/products\/new-product-223215","provider":"Dana Bioscience","version":"1.0","type":"link"}