{"product_id":"new-product-222765","title":"F4\/80 Rat monoclonal antibody","description":"\u003cp\u003eThe epidermal growth factor (EGF)-TM7 family constitutes a group of class B G-protein coupled receptors, which includes CD97, EMR1 (EGF-like molecule containing mucin-like hormone receptor 1, designated F4\/80 in mouse), EMR2, EMR3, FIRE, and ETL. These family members are characterized by an extended extracellular region with several N-terminal EGF domains, and are predominantly expressed on cells of the immune system. The EGF-TM7 protein family are encoded by a gene cluster on human chromosome 19p13. The F4\/80 molecule is solely expressed on the surface of macrophages and serves as a marker for mature macrophage tissues, including Kupffer cells in liver, splenic red pulp macrophages, brain microglia, gut lamina propria, and Langerhans cells in the skin. F4\/80\/EMR1 undergoes extensive N-linked glycosylation as well as some O-linked glycosylation. The function of F4\/80\/EMR1 is unclear, but it is speculated to be involved in macrophage adhesion events, cell migration, or as a G-protein coupled signaling component of macrophages.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rat \/ Human, Mouse","offer_id":47661483295000,"sku":"RB0001","price":448.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_0db0bbd7-30cb-4db9-a72b-a929cade6167.jpg?v=1707456054","url":"https:\/\/danabiosci.com\/products\/new-product-222765","provider":"Dana Bioscience","version":"1.0","type":"link"}