{"product_id":"n1201-25ug","title":"TAB3 Antibody","description":"\u003cp\u003eTAB3, a TAB2-like protein, is a mediator of TAK1 activation in IL-1 and TNF signaling. IL-1 and TNF are cytokines involved in the inflammation process, initiating signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (MAPKs). TAB3 functions as an adapter, linking TAK1 and TRAF6 or TRAF2. This kinase complex phosphorylates IkB, which keeps NF-kB inactive and sequestered in the cytoplasm. Phosphorylation leads to IkB degradation, activating NF-kB, which translocates to the nucleus, binds to DNA response elements and can begin multiple signaling cascades.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"25 ug \/ Rabbit","offer_id":49477003280664,"sku":"N1201-25UG","price":219.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_812a30e6-c613-46bc-9469-a700c787c190.jpg?v=1734486691","url":"https:\/\/danabiosci.com\/products\/n1201-25ug","provider":"Dana Bioscience","version":"1.0","type":"link"}