{"product_id":"n1151-25ug","title":"S100A8 Antibody","description":"\u003cp\u003eThe S100 family of proteins are found in vertebrates and are characterized by two calcium-binding sites that have a helix-loop-helix conformation. The family of 24 is divided into three subgroups based on function: those with intracellular, intracellular plus extracellular, and extracellular regulatory effects. The calcium-binding protein S100A8, also called MRP8 or Myeloid-related protein 8, and Calgranulin A, forms a heterodimer with S100A9, called Calprotectin. The heterodimer is expressed by granulocytes, monocytes, and early differentiation states of macrophages, and is known to be an important pro-inflammatory mediator in acute and chronic inflammation. S100A8 and 9 are DAMPs, or Damage-associated molecular pattern molecules, and are able to activate receptors of the innate immune system, one being TLR4.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"25 ug \/ Mouse","offer_id":49477004394776,"sku":"N1151-25UG","price":219.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_80403839-0824-4db5-8a45-786f7055f260.jpg?v=1734486776","url":"https:\/\/danabiosci.com\/products\/n1151-25ug","provider":"Dana Bioscience","version":"1.0","type":"link"}