{"product_id":"n1090-25ug","title":"DC-SIGN Antibody","description":"\u003cp\u003eDC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209, is part of the Lectin family of proteins. DC-SIGN is part of the innate immune response via its modulation of Toll-like Receptors. It is present on the surface of macrophages and dendritic cells and binds mannose carbohydrates, a class of PAMPS found on bacteria, fungi and viruses. PAMP stimulated DC-SIGN activates the Raf kinases Raf-1 and B-Raf. Raf-1 phosphorylates Ser276 of NF-kB p65 which serves as a binding site for histone acetyltransferases CREB-binding protein (CBP) and p300. Acetylation of NF-kB p65 leads to enhanced and prolonged anti-inflammatory cytokine IL-10 production.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"25 ug \/ Rabbit","offer_id":49477006360856,"sku":"N1090-25UG","price":219.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_5b368568-e2fb-4453-80bd-106be3e9804e.jpg?v=1734486926","url":"https:\/\/danabiosci.com\/products\/n1090-25ug","provider":"Dana Bioscience","version":"1.0","type":"link"}