{"product_id":"lat-phospho-tyr255-rabbit-polyclonal-antibody-abcb08756","title":"LAT(Phospho Tyr255) Rabbit Polyclonal Antibody","description":"\u003ch4\u003eAb type\u003c\/h4\u003e\u003cp\u003ePrimary antibody\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eRequired for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling| both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores| PKC activation| MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1| GRB2| GRAP2| and other signaling molecules.|miscellaneous:Engagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1 with LAT and blocks target cell-induced activation of PLC| maybe by inducing the dephosphorylation of LAT.|PTM:Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.|PTM:Phosphorylated on tyrosines by ZAP-70 upon TCR activation| or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement.|subcellular location:Present in lipid rafts.|subunit:When phosphorylated| interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2| GRAP| GRAP2| PLCG1 and PLCG2. Interacts indirectly with CBL| SOS| VAV| and LCP2. Interacts with SHB| SKAP2 and CLNK (By similarity). Interacts with FCGR1A.|tissue specificity:Expressed in thymus| T-cells| NK cells| mast cells and| at lower levels| in spleen. Present in T-cells but not B-cells (at protein level).|\u003c\/p\u003e\u003ch4\u003eReactivity\u003c\/h4\u003e\u003cp\u003eHuman, Mouse, Rat\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eHost\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eSynthesized peptide derived from human LAT (Phospho Tyr255)\u003c\/p\u003e\u003ch4\u003eStorage Stability\u003c\/h4\u003e\u003cp\u003e-20°C for 1 year\u003c\/p\u003e\u003ch4\u003eConcentration\u003c\/h4\u003e\u003cp\u003e1 mg\/ml\u003c\/p\u003e\u003ch4\u003eMolecularWeight_Da\u003c\/h4\u003e\u003cp\u003e28820\u003c\/p\u003e\u003ch4\u003esynonyms\u003c\/h4\u003e\u003cp\u003eLAT ;Phospho Tyr255; Linker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein; pp36; p36-38\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":42404633411818,"sku":"ABCB08756","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_65da3c93-049b-42f5-a816-671cdbc0798a.png?v=1645225617","url":"https:\/\/danabiosci.com\/products\/lat-phospho-tyr255-rabbit-polyclonal-antibody-abcb08756","provider":"Dana Bioscience","version":"1.0","type":"link"}