{"product_id":"lamin-a-c-phospho-ser392-polyclonal-antibody-abcb06759","title":"Lamin A\/C(Phospho Ser392) Polyclonal Antibody","description":"\u003ch4\u003eAb type\u003c\/h4\u003e\u003cp\u003ePrimary antibody\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eThe nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis| the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability| chromatin structure and gene expression. Vertebrate lamins consist of two types| A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy| familial partial lipodystrophy| limb girdle muscular dystrophy| dilated cardiomyopathy| Charcot-Marie-Tooth disease| and Hutchinson-Gilford progeria syndrome. \u003c\/p\u003e\u003ch4\u003eReactivity\u003c\/h4\u003e\u003cp\u003eHuman, Mouse, Rat\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eHost\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eThe antiserum was produced against synthesized peptide derived from human Lamin A\/C around the phosphorylation site of Ser392. AA range:361-410\u003c\/p\u003e\u003ch4\u003eStorage Stability\u003c\/h4\u003e\u003cp\u003e-20°C for 1 year\u003c\/p\u003e\u003ch4\u003eConcentration\u003c\/h4\u003e\u003cp\u003e1 mg\/ml\u003c\/p\u003e\u003ch4\u003eMolecularWeight_Da\u003c\/h4\u003e\u003cp\u003e74139\u003c\/p\u003e\u003ch4\u003esynonyms\u003c\/h4\u003e\u003cp\u003ePrelamin-A\/C; LMNA; LMN1; Prelamin-A\/C\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":42404483399914,"sku":"ABCB06759","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_79f672f2-49d1-420b-a615-33570b85a715.png?v=1645222341","url":"https:\/\/danabiosci.com\/products\/lamin-a-c-phospho-ser392-polyclonal-antibody-abcb06759","provider":"Dana Bioscience","version":"1.0","type":"link"}