ABCbiolab
SKU:ABCCS62788
KANK2 Antibody
KANK2 Antibody
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Size
100ug
Clone Number
Aliases
KANK2 antibody; ANKRD25 antibody; KIAA1518 antibody; MXRA3 antibody; SIP antibody; KN motif and ankyrin repeat domain-containing protein 2 antibody; Ankyrin repeat domain-containing protein 25 antibody; Matrix-remodeling-associated protein 3 antibody; SRC-1-interacting protein antibody; SIP antibody; SRC-interacting protein antibody; SRC1-interacting protein antibody
Immunogen Species
Homo sapiens (Human)
UniProt ID
Q63ZY3
Immunogen
Recombinant Human KN motif and ankyrin repeat domain-containing protein 2 protein (410-585AA)
Raised in
Rabbit
Species Reactivity
Human
Tested Applications
ELISA, IHC; Recommended dilution: IHC:1:200-1:500
Background
Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500). May be involved in promotion of cell proliferation (By similarity).
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Conjugate
Non-conjugated
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Stroage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names
KANK2
Research Areas
Others