{"product_id":"fzr1-antibody-abccs43724","title":"FZR1 Antibody","description":"\u003ch4\u003eSize\u003c\/h4\u003e\u003cp\u003e100ug\u003c\/p\u003e\u003ch4\u003eClone Number\u003c\/h4\u003e\u003cp\u003e\u003c\/p\u003e\u003ch4\u003eAliases\u003c\/h4\u003e\u003cp\u003eCDC20 like 1b antibody; CDC20 like protein 1 antibody; CDC20-like protein 1 antibody; CDC20C antibody; CDH1 antibody; Cdh1\/Hct1 homolog antibody; Fizzy related protein 1 antibody; Fizzy related protein antibody; Fizzy related protein homolog antibody; Fizzy-related protein homolog antibody; Fizzy\/cell division cycle 20 related 1 antibody; FYR antibody; FZR 1 antibody; FZR 2 antibody; Fzr antibody; FZR_HUMAN antibody; Fzr1 antibody; Fzr1 protein antibody; FZR2 antibody; HCDH 1 antibody; HCDH antibody; hCDH1 antibody; KIAA1242 antibody\u003c\/p\u003e\u003ch4\u003eImmunogen Species\u003c\/h4\u003e\u003cp\u003eHomo sapiens (Human)\u003c\/p\u003e\u003ch4\u003eUniProt ID\u003c\/h4\u003e\u003cp\u003eQ9UM11\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eRecombinant Human Fizzy-related protein homolog protein (1-493AA)\u003c\/p\u003e\u003ch4\u003eRaised in\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eSpecies Reactivity\u003c\/h4\u003e\u003cp\u003eHuman\u003c\/p\u003e\u003ch4\u003eTested Applications\u003c\/h4\u003e\u003cp\u003eELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eKey regulator of ligase activity of the anaphase promoting complex\/cyclosome (APC\/C), which confers substrate specificity upon the complex. Associates with the APC\/C in late mitosis, in replacement of CDC20, and activates the APC\/C during anaphase and telophase. The APC\/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1\/S transition FZR1 is phosphorylated, leading to its dissociation from the APC\/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC\/C leads to the ubiquitination of PLK1, preventing entry into mitosis.\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003ePurification Method\u003c\/h4\u003e\u003cp\u003e\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003ch4\u003eConjugate\u003c\/h4\u003e\u003cp\u003eNon-conjugated\u003c\/p\u003e\u003ch4\u003eBuffer\u003c\/h4\u003e\u003cp\u003ePreservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, PH 7.4\u003c\/p\u003e\u003ch4\u003eForm\u003c\/h4\u003e\u003cp\u003eLiquid\u003c\/p\u003e\u003ch4\u003eStroage\u003c\/h4\u003e\u003cp\u003eUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003ch4\u003eTarget Names\u003c\/h4\u003e\u003cp\u003eFZR1\u003c\/p\u003e\u003ch4\u003eResearch Areas\u003c\/h4\u003e\u003cp\u003eCell biology\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"Default Title","offer_id":42364124725482,"sku":"ABCCS43724","price":299.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_a1c4ef19-8604-49e7-9427-658dd0f4e9bc.png?v=1650897779","url":"https:\/\/danabiosci.com\/products\/fzr1-antibody-abccs43724","provider":"Dana Bioscience","version":"1.0","type":"link"}