{"product_id":"fy-ig0445-1","title":"50\/100","description":"\u003cstrong\u003eName:\u003c\/strong\u003e Cleaved PARP Mouse Monoclonal Antibody(M4)\u003cbr\u003e\u003cstrong\u003eCondition:\u003c\/strong\u003e 1mg\/ml in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol.\u003cbr\u003e\u003cstrong\u003eStore at:\u003c\/strong\u003e Store at -20°C. Stable for one year from the date of shipment.\u003cbr\u003e\u003cstrong\u003eRecommended dilutions:\u003c\/strong\u003e WB 1:1,000-3,000  IHC 1:200-500\u003cbr\u003e\u003cstrong\u003eSpecificity:\u003c\/strong\u003e Antibody can detect endogenous pro and active PARP proteins.\u003cbr\u003e\u003cstrong\u003eAlternative Names:\u003c\/strong\u003e PARP-1,Poly(ADP ribose) polymerase 1,sPARP1,ADPRT1,ADP ribosyltransferase NAD(+)\u003cbr\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1,when these breaks are encountered during DNA replication,the replication fork stalls,and double-strand DNA (dsDNA) breaks accumulate.\u003cbr\u003e\u003cstrong\u003eApplications:\u003c\/strong\u003e WB,IHC\u003cbr\u003e\u003cstrong\u003eSpecies Cross-Reactivity:\u003c\/strong\u003e H\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 116KD(Pro),89(Active)\u003cbr\u003e\u003cstrong\u003eProtein MW    （KDa）:\u003c\/strong\u003e 116,89KD\u003cbr\u003e\u003cstrong\u003eSWISS:\u003c\/strong\u003e P09874\u003cbr\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e Mouse\u003cbr\u003e\u003cstrong\u003eAntigen:\u003c\/strong\u003e Synthetic Peptide\u003cbr\u003e\u003cstrong\u003eCategory:\u003c\/strong\u003e Monoclonal\u003cbr\u003e\u003cstrong\u003eCatalog Number:\u003c\/strong\u003e FY-IG0445\u003cbr\u003e\u003cstrong\u003eTitle:\u003c\/strong\u003e 50\/100\u003cbr\u003e\u003cstrong\u003eSize Raw:\u003c\/strong\u003e IgG1\u003cbr\u003e\u003cstrong\u003eSize List:\u003c\/strong\u003e ['1']","brand":"Feiyuebio","offers":[{"title":"1","offer_id":50353326129432,"sku":"FY-IG0445-1","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/Feiyuebio_efafb92f-aa7e-4cfa-91ba-b7f0c5b7f839.png?v=1749697418","url":"https:\/\/danabiosci.com\/products\/fy-ig0445-1","provider":"Dana Bioscience","version":"1.0","type":"link"}