{"product_id":"fy-ig0237-1","title":"50\/100","description":"\u003cstrong\u003eName:\u003c\/strong\u003e PDGFRα Mouse Monoclonal Antibody(7A3)\u003cbr\u003e\u003cstrong\u003eCondition:\u003c\/strong\u003e 1mg\/ml in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol.\u003cbr\u003e\u003cstrong\u003eStore at:\u003c\/strong\u003e Store at -20°C. Stable for one year from the date of shipment.\u003cbr\u003e\u003cstrong\u003eRecommended dilutions:\u003c\/strong\u003e IHC 1:100-200\u003cbr\u003e\u003cstrong\u003eSpecificity:\u003c\/strong\u003e Antibody can detect endogenous PDGFRα proteins.\u003cbr\u003e\u003cstrong\u003eAlternative Names:\u003c\/strong\u003e nan\u003cbr\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e Platelet derived growth factor (PDGF) family proteins exist as several disulphide-bonded,dimeric isoforms (PDGF AA,PDGF AB,PDGF BB,PDGF CC,and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases,PDGF receptor α (PDGFRα) and PDGF receptor β (PDGFRβ). PDGFRα and PDGFRβ can each form heterodimers with EGFR,which is also activated by PDGF. Various cells differ in the total number of receptors present and in the receptor subunit composition,which may account for responsive differences among cell types to PDGF binding. Ligand binding induces receptor dimerization and autophosphorylation,followed by binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules,such as GRB2,Src,GAP,PI3 kinase,PLCγ,and NCK. A number of different signaling pathways are initiated by activated PDGF receptors and lead to control of cell growth,actin reorganization,migration,and differentiation.\u003cbr\u003e\u003cstrong\u003eApplications:\u003c\/strong\u003e IHC\u003cbr\u003e\u003cstrong\u003eSpecies Cross-Reactivity:\u003c\/strong\u003e H,M,R\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 180KD\u003cbr\u003e\u003cstrong\u003eProtein MW    （KDa）:\u003c\/strong\u003e 180KD\u003cbr\u003e\u003cstrong\u003eSWISS:\u003c\/strong\u003e P16234\u003cbr\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e Mouse\u003cbr\u003e\u003cstrong\u003eAntigen:\u003c\/strong\u003e Synthetic Peptide\u003cbr\u003e\u003cstrong\u003eCategory:\u003c\/strong\u003e Monoclonal\u003cbr\u003e\u003cstrong\u003eCatalog Number:\u003c\/strong\u003e FY-IG0237\u003cbr\u003e\u003cstrong\u003eTitle:\u003c\/strong\u003e 50\/100\u003cbr\u003e\u003cstrong\u003eSize Raw:\u003c\/strong\u003e IgG1\u003cbr\u003e\u003cstrong\u003eSize List:\u003c\/strong\u003e ['1']","brand":"Feiyuebio","offers":[{"title":"1","offer_id":50353311973656,"sku":"FY-IG0237-1","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/Feiyuebio_fdf0257d-8f77-4ef8-9d37-b82a5e2a9110.png?v=1749696822","url":"https:\/\/danabiosci.com\/products\/fy-ig0237-1","provider":"Dana Bioscience","version":"1.0","type":"link"}