{"product_id":"fy-ig0230-100","title":"MLKL(Phospho Ser358) Mouse Monoclonal Antibody(6F8)","description":"\u003cstrong\u003eCondition:\u003c\/strong\u003e 1mg\/ml in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol.\u003cbr\u003e\u003cstrong\u003eStore at:\u003c\/strong\u003e Store at -20°C. Stable for one year from the date of shipment.\u003cbr\u003e\u003cstrong\u003eRecommended dilutions:\u003c\/strong\u003e IHC 1:100-200\u003cbr\u003e\u003cstrong\u003eSpecificity:\u003c\/strong\u003e Antibody can detect endogenous Phospho ser358 MLKL proteins.\u003cbr\u003e\u003cstrong\u003eAlternative Names:\u003c\/strong\u003e Mixed lineage kinase domain like protein,FLJ34389\u003cbr\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase that was identified as downstream target of RIP3 in the necroptosis pathway. During necroptosis RIP3 is phosphorylated at Ser227,which recruits MLKL and leads to its phosphorylation at Thr357 and Ser358.\u003cbr\u003e\u003cstrong\u003eApplications:\u003c\/strong\u003e IHC\u003cbr\u003e\u003cstrong\u003eSpecies Cross-Reactivity:\u003c\/strong\u003e H\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 54KD\u003cbr\u003e\u003cstrong\u003eIsotype:\u003c\/strong\u003e IgG1\u003cbr\u003e\u003cstrong\u003eProtein MW    （KDa）:\u003c\/strong\u003e 54KD\u003cbr\u003e\u003cstrong\u003eSWISS:\u003c\/strong\u003e Q8NB16\u003cbr\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e Mouse\u003cbr\u003e\u003cstrong\u003eAntigen:\u003c\/strong\u003e Synthetic Peptide\u003cbr\u003e\u003cstrong\u003eCategory:\u003c\/strong\u003e Monoclonal\u003cbr\u003e\u003cstrong\u003eCatalog Number:\u003c\/strong\u003e FY-IG0230\u003cbr\u003e\u003cstrong\u003eTitle:\u003c\/strong\u003e MLKL(Phospho Ser358) Mouse Monoclonal Antibody(6F8)\u003cbr\u003e\u003cstrong\u003eSize List:\u003c\/strong\u003e ['50', '100']","brand":"Feiyuebio","offers":[{"title":"100","offer_id":50359047029016,"sku":"FY-IG0230-100","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/Feiyuebio_3a5842bf-06e5-4309-ad66-8016ce0b5e7d.png?v=1749883045","url":"https:\/\/danabiosci.com\/products\/fy-ig0230-100","provider":"Dana Bioscience","version":"1.0","type":"link"}