{"product_id":"fbxw7-antibody-hrp-conjugated-abccs53709","title":"FBXW7 Antibody, HRP conjugated","description":"\u003ch4\u003eSize\u003c\/h4\u003e\u003cp\u003e100ug\u003c\/p\u003e\u003ch4\u003eClone Number\u003c\/h4\u003e\u003cp\u003e\u003c\/p\u003e\u003ch4\u003eAliases\u003c\/h4\u003e\u003cp\u003eAGO antibody; Archipelago antibody; Archipelago homolog antibody; Archipelago, Drosophila, homolog of antibody; CDC4 antibody; CDC4, S.cerevisiae, homolog of antibody; DKFZp686F23254 antibody; F box and WD 40 domain protein 7 (archipelago homolog, Drosophila) antibody; F box and WD 40 domain protein 7 antibody; F box and WD repeat domain containing 7 antibody; F box protein FBW7 antibody; F box protein FBX30 antibody; F box protein SEL 10 antibody; F box protein SEL10 antibody; F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase antibody; F-box and WD-40 domain-containing protein 7 antibody; F-box protein FBX30 antibody; F-box\/WD repeat-containing protein 7 antibody; FBW6 antibody; FBW7 antibody; FBX30 antibody; FBXO30 antibody; FBXW6 antibody; FBXW7 antibody; FBXW7_HUMAN antibody; FLJ16457 antibody; hAgo antibody; hCdc4 antibody; Homolog of C elegans sel 10 antibody; Homolog of C.elegans sel10 antibody; SEL 10 antibody; SEL-10 antibody; SEL10 antibody\u003c\/p\u003e\u003ch4\u003eImmunogen Species\u003c\/h4\u003e\u003cp\u003eHomo sapiens (Human)\u003c\/p\u003e\u003ch4\u003eUniProt ID\u003c\/h4\u003e\u003cp\u003eQ969H0\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eRecombinant Human F-box\/WD repeat-containing protein 7 protein (1-707AA)\u003c\/p\u003e\u003ch4\u003eRaised in\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eSpecies Reactivity\u003c\/h4\u003e\u003cp\u003eHuman\u003c\/p\u003e\u003ch4\u003eTested Applications\u003c\/h4\u003e\u003cp\u003eELISA\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eSubstrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites\/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463).\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003ePurification Method\u003c\/h4\u003e\u003cp\u003e\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003ch4\u003eConjugate\u003c\/h4\u003e\u003cp\u003eHRP\u003c\/p\u003e\u003ch4\u003eBuffer\u003c\/h4\u003e\u003cp\u003ePreservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, pH 7.4\u003c\/p\u003e\u003ch4\u003eForm\u003c\/h4\u003e\u003cp\u003eLiquid\u003c\/p\u003e\u003ch4\u003eStroage\u003c\/h4\u003e\u003cp\u003eUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003ch4\u003eTarget Names\u003c\/h4\u003e\u003cp\u003eFBXW7\u003c\/p\u003e\u003ch4\u003eResearch Areas\u003c\/h4\u003e\u003cp\u003eCancer; Cell biology\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"Default Title","offer_id":42297504301290,"sku":"ABCCS53709","price":299.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_7c3d1167-a8b7-4795-b03b-12aeb0623c36.png?v=1650706625","url":"https:\/\/danabiosci.com\/products\/fbxw7-antibody-hrp-conjugated-abccs53709","provider":"Dana Bioscience","version":"1.0","type":"link"}