{"product_id":"f54223-0-4ml","title":"ACVR1 Antibody \/ ALK2","description":"\u003cp\u003eActivins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine\/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 (activin A type I receptor) signals a particular transcriptional response in concert with activin type II receptors.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.4ml \/ Rabbit","offer_id":49477201395992,"sku":"F54223-0.4ML","price":429.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_48e884a3-64c9-4606-b89b-a49d24ee8466.jpg?v=1734492434","url":"https:\/\/danabiosci.com\/products\/f54223-0-4ml","provider":"Dana Bioscience","version":"1.0","type":"link"}