{"product_id":"f54084-0-2ml","title":"Raf1 Antibody \/ c-Raf","description":"\u003cp\u003eSerine\/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK\/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1\/MEK1 and MAP2K2\/MEK2) and the extracellular signal-regulated kinases (MAPK3\/ERK1 and MAPK1\/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD\/Bcl2- antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2\/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5\/ASK1 and STK3\/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD\/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2\/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. [UniProt]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.2 ml \/ Rabbit","offer_id":49477229642008,"sku":"F54084-0.2ML","price":429.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_68c95dc6-ab40-41ed-b600-7227ce276a1f.jpg?v=1734493256","url":"https:\/\/danabiosci.com\/products\/f54084-0-2ml","provider":"Dana Bioscience","version":"1.0","type":"link"}