{"product_id":"f54049-0-1ml","title":"CDK4 Antibody","description":"\u003cp\u003eSer\/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1\/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB\/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D\/CDK4\/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. [UniProt]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.1 ml \/ Mouse","offer_id":49477239013656,"sku":"F54049-0.1ML","price":429.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_f311bb03-41e4-4e82-abb5-94aaa21eb8b5.jpg?v=1734493444","url":"https:\/\/danabiosci.com\/products\/f54049-0-1ml","provider":"Dana Bioscience","version":"1.0","type":"link"}