{"product_id":"f54014-0-1ml","title":"Beta Arrestin 1 Antibody","description":"\u003cp\u003eFunctions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. [UniProt]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.1 ml \/ Mouse","offer_id":49477242323224,"sku":"F54014-0.1ML","price":429.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_0c900b9f-2c67-4b6e-95f1-1b54f53e3f64.jpg?v=1734493536","url":"https:\/\/danabiosci.com\/products\/f54014-0-1ml","provider":"Dana Bioscience","version":"1.0","type":"link"}