{"product_id":"f53819-0-2ml","title":"SAM68 Antibody \/ Src associated in mitosis 68 kDa protein","description":"\u003cp\u003eSrc associated in mitosis 68 kDa protein is recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and\/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.2 ml \/ Rabbit","offer_id":49477303992600,"sku":"F53819-0.2ML","price":429.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_7107e40a-2ff1-44a9-8cd7-dca1fa8d44dd.jpg?v=1734494650","url":"https:\/\/danabiosci.com\/products\/f53819-0-2ml","provider":"Dana Bioscience","version":"1.0","type":"link"}