{"product_id":"f53804-0-2ml","title":"FZR1 Antibody \/ Fizzy related protein 1","description":"\u003cp\u003eFizzy related protein 1 is a key regulator of ligase activity of the anaphase promoting complex\/cyclosome (APC\/C), which confers substrate specificity upon the complex. Associates with the APC\/C in late mitosis, in replacement of CDC20, and activates the APC\/C during anaphase and telophase. The APC\/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1\/S transition FZR1 is phosphorylated, leading to its dissociation from the APC\/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC\/C leads to the ubiquitination of PLK1, preventing entry into mitosis.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.2 ml \/ Mouse","offer_id":49477307498776,"sku":"F53804-0.2ML","price":429.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_600a1196-ef62-408b-ac73-8fccc9a93b69.jpg?v=1734494750","url":"https:\/\/danabiosci.com\/products\/f53804-0-2ml","provider":"Dana Bioscience","version":"1.0","type":"link"}