{"product_id":"f52880-0-4ml","title":"Egfr Antibody","description":"\u003cp\u003eReceptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA\/TGF-alpha, amphiregulin, epigen\/EPGN, BTC\/betacellulin, epiregulin\/EREG and HBEGF\/heparin-binding EGF. Ligand binding triggers receptor homo- and\/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1\/beta-catenin.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml \/ Rabbit","offer_id":49477373034776,"sku":"F52880-0.4ML","price":429.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_de1b9ac9-7dff-49d6-9614-9ae53c269c78.jpg?v=1734496115","url":"https:\/\/danabiosci.com\/products\/f52880-0-4ml","provider":"Dana Bioscience","version":"1.0","type":"link"}