{"product_id":"f52344-0-4ml","title":"SUMO-2 Antibody","description":"\u003cp\u003eUbiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml \/ Mouse","offer_id":49477488869656,"sku":"F52344-0.4ML","price":429.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_bf15f545-6052-41cc-a2c4-cc6abc8d70c3.jpg?v=1734496768","url":"https:\/\/danabiosci.com\/products\/f52344-0-4ml","provider":"Dana Bioscience","version":"1.0","type":"link"}