{"product_id":"f52327-0-4ml","title":"TICAM1 Antibody","description":"Involved in innate immunity against invading pathogens. Adapter used by \u003ca href=\"..\/search_result.php?search_txt=TLR\"\u003eTLR3\u003c\/a\u003e and \u003ca href=\"..\/search_result.php?search_txt=TLR\"\u003eTLR4\u003c\/a\u003e (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins \u003ca href=\"..\/search_result.php?search_txt=Tbk1\"\u003eTBK1\u003c\/a\u003e, TRAF6 and \u003ca href=\"..\/search_result.php?search_txt=ripk\"\u003eRIPK1\u003c\/a\u003e, which in turn, lead to the activation of transcription factors IRF3 and IRF7, \u003ca href=\"..\/search_result.php?search_txt=nf-kb\"\u003eNF-kappa-B\u003c\/a\u003e and FADD respectively.","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml \/ Rabbit","offer_id":49477492539672,"sku":"F52327-0.4ML","price":429.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_e5ee9e61-c682-4667-b99e-3d3bcb8a83ed.jpg?v=1734496806","url":"https:\/\/danabiosci.com\/products\/f52327-0-4ml","provider":"Dana Bioscience","version":"1.0","type":"link"}