{"product_id":"f52197-0-4ml","title":"Cyclin D2 Antibody (CCND2)","description":"\u003cp\u003eRegulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)\/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB\/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2\/CDK4\/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml \/ Rabbit","offer_id":49477500272920,"sku":"F52197-0.4ML","price":429.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_b1683f71-922e-4633-8de1-8d1a965f8e4a.jpg?v=1734496936","url":"https:\/\/danabiosci.com\/products\/f52197-0-4ml","provider":"Dana Bioscience","version":"1.0","type":"link"}