{"product_id":"f51969-0-4ml","title":"AIM2 Antibody","description":"\u003cp\u003eInvolved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. [UniProt]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml \/ Rabbit","offer_id":49477542150424,"sku":"F51969-0.4ML","price":429.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_a75eacd4-f609-4a33-928b-6e506a2ca06e.jpg?v=1734497239","url":"https:\/\/danabiosci.com\/products\/f51969-0-4ml","provider":"Dana Bioscience","version":"1.0","type":"link"}