{"product_id":"f50890-0-08ml","title":"PAK1 Antibody","description":"\u003cp\u003ePAK1, a member of the STE20 subfamily of Ser\/Thr protein kinases, acts on a variety of targets. It is likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. The protein interacts tightly with GTP-bound but not GDP-bound CDC42\/P21 and RAC1. PAK1 binds to the caspase-cleaved p110 isoform of CDC2L1 and CDC2L2, p110C, but not the full-length proteins. It is a component of cytoplasmic complexes, which also contain PXN, ARHGEF6 and GIT1. The protein is autophosphorylated when activated by CDC42\/p21. Structurally, the PAK1 contains 1 CRIB domain.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.08 ml \/ Rabbit","offer_id":49477749834008,"sku":"F50890-0.08ML","price":199.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_1897808e-95ed-428b-9264-1723b0e23ee2.jpg?v=1734498153","url":"https:\/\/danabiosci.com\/products\/f50890-0-08ml","provider":"Dana Bioscience","version":"1.0","type":"link"}