{"product_id":"f50316-0-4ml","title":"CD163 Antibody","description":"\u003cp\u003eCD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin\/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin\/haptoglobin and subsequent breakdown of heme. It binds hemoglobin\/haptoglobin complexes in a calcium-dependent and pH-dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml \/ Rabbit","offer_id":49477806719256,"sku":"F50316-0.4ML","price":429.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_153802ac-1e21-41fe-8e1e-63e0ca8b5a45.jpg?v=1734499382","url":"https:\/\/danabiosci.com\/products\/f50316-0-4ml","provider":"Dana Bioscience","version":"1.0","type":"link"}