{"product_id":"f49681-0-2ml","title":"VHL Antibody","description":"\u003cp\u003eVon Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL gene is the basis of familial inheritance of VHL syndrome. The protein is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G\/RPB7 is also reported to be a target of this protein.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.2 ml \/ Rabbit","offer_id":49477828247832,"sku":"F49681-0.2ML","price":429.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_7b08cf5f-54cd-463a-a551-9884be5db20a.jpg?v=1734500290","url":"https:\/\/danabiosci.com\/products\/f49681-0-2ml","provider":"Dana Bioscience","version":"1.0","type":"link"}