{"product_id":"f48701-0-4ml","title":"Phospho-IKK beta Antibody (pS670)","description":"\u003cp\u003eNFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml \/ Rabbit","offer_id":49477857018136,"sku":"F48701-0.4ML","price":429.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_2c2c46eb-23b7-4c02-be43-74c5040a0632.jpg?v=1734501443","url":"https:\/\/danabiosci.com\/products\/f48701-0-4ml","provider":"Dana Bioscience","version":"1.0","type":"link"}