{"product_id":"f48111-0-4ml","title":"Cyclin D1 Antibody (CCND1)","description":"\u003cp\u003eCCND1 is the regulatory component of the Cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)\/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB\/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. CyclinD-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. [UniProt]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml \/ Rabbit","offer_id":49477893882136,"sku":"F48111-0.4ML","price":429.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_a240c170-2e2f-4f76-a7f8-ea3819ef3f5e.jpg?v=1734502601","url":"https:\/\/danabiosci.com\/products\/f48111-0-4ml","provider":"Dana Bioscience","version":"1.0","type":"link"}